跳到主要內容區

林文文 副教授 (2020年2月1日退休)

Members
退休教師

  • 林文文 副教授 (2020年2月1日退休)

    林文文 副教授 (2020年2月1日退休)
     
    學歷美國加州大學內分泌研究群博士
    研究領域分子調控在水族生物生理與育種之應用
    學術專長分子內分泌、基因表現調控、動物生理生化
    E-mailwwlin@nkust.edu.tw

     

    研究領域 Research Interests
    領域：基因在胚胎發育時期的功能。
    主題：
    1.探討斑馬魚gpia、gpib及其受器amfr在胚胎發育中的基因功能。
    2.AMFR所調控的下游基因，對卵黃融合細胞層功能的影響。
     
    背景：
    葡萄糖磷酸異構 (GPI)又名自分泌移動因子(AMF)，在哺乳動物是一個具有多種功能的蛋白質。它在細胞內是一個糖類代謝過程的重要酵素。當它被分泌至細胞外時，則展現細胞激素(cytokine)的特性，可和它的膜受器結合(自分泌移動因子受器AMFR)，誘導鄰近細胞的活性。AMFR在內質網膜上又可扮演E3 ligase的角色，促進蛋白質的泛素化及降解。
     
    研究方法：
    1.以定位雜交法分析各發育時期基因的表現位置。
    2.採用反義股morpholino RNA顯微注射胚胎，抑 制基因表現，觀察胚胎的發育表現型。
    3.以分析早期胚胎組織的分子標記，來探討gpia、gpib及amfr影響早期胚胎發育的分子機制。
     

     

    著作 Publications
    (一)國際期刊論文International journal articles
    Yao-Feng Tsao, Wen-Wen Lin, Chia-Hao Chang, Takayoshi Ueda, Nian-Hong Jang-Liaw, Ya-Hui Zhao, and Hsiao-Wei Kao (2016) Phylogeography, Historical Demography, and Genetic Structure ofthe Rose Bitterling, Rhodeus ocellatus (Kner, 1866) (Cypriniformes: Acheilognathidae), in East Asia. Zoological Studies 55:49

    Shih, YS, Chen, CY, Lin, WW, Kao, HW (2014) Mycena kentingensis, a new species of luminous mushroom in Taiwan, with reference to its culture method. Mycol Progress 13:429-435
     
    Lin, JI, Lin, WW, Kao, HW. (2012) The complete mitochondrial genome of the mackerel icefish, Champsocephalus gunnari (Actinopterygii: Channichthyidae), with reference to the evolution of mitochondrial genomes in Antarctic notothenioids. Zoological Journal of the Linnean Society 165:521-533
     
    Hong, MC, Huang, YS, Song, PC, Lin, WW, Fang, LS, Chen, MC. (2009) Cloning and characterization of ApRab4, a recycling Rab protein of Aiptasia pulchella, and its implication in the symbiosome biogenesis. Mar. Biotechnol. 11:771-785
     
    Chang, CH, Lin, WW, Shao, YT, Arai, R, Ishinabe, T, Ueda, T, Matsuda, M, Kubota, H,  Wang, FY, Jang-Liaw, NH, Kao, HW. (2009) Molecular phylogeny and genetic    differentiation of Tanakia himantegus complex (Teleostei: Cyprinidae) in Taiwan and  mainland China. Zoological Studies 48(6):823-834
     
    Ke, HM, Lin, WW, Kao, HW. (2009) Genetic diversity and differentiation of gray mullet (Mugil cephalus) in the coastal waters of Taiwan. Zoological Science 26(6):421-428
     
    Lin, WW, Chen, LH, Chen, MC, Kao, HW. (2009) Differential expression of zebrafish gpia and gpib during development. Gene Expr. Patterns 9(4):238-245
     
    Hong, MC, Huang, YS, Lin, WW, Fang, LS, Chen, MC. (2009) ApRab3, a biosynthetic Rab protein, accumulates on the maturing phagosomes and symbiosomes in the tropical sea anemone, Aiptasia pulchella. Comp. Biochem. Physiol. B Biochem. Mol.   Biol. 152(3):249-259
     
    Sheela, SG, Lee, WC, Lin, WW, Chung, BC. (2005) Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization. Dev. Biol. 286(2):377-390
     
    Lin, WW, Wang, HW, Sum, C, Chen, JC, Liu, D, Hew, CL, Chung, BC (2000) Zebrafish ftz-f1 gene has two promoters, is alternatively spliced, and expressed in digestive organs. Biochemical J. 348:439-446
     
    Lin, WW, Oberbauer, AM (1999) Spatiotemporal expression of alternatively spliced IGF-I mRNA in the rat costochondral growth plate. Journal of Endocrinology 160(3):461-467
     
    Lin, WW, Murray, JD, Oberbauer, AM (1998) Overexpression of growth hormone affects alternatively spliced IGF-I mRNA expression in oMt1a-oGH transgenic mice. Transgenic Research 7:295-302
     
    Lin, WW, Oberbauer, AM (1998) Alternative splicing of insulin-like growth factor I mRNA is developmentally regulated in the rat and mouse with preferential exon 2 usage in the mouse. Growth Hormone and IGF Research 8:225-233
     
    Kuo, CM, Lin, WW (1996) Changes in morphological characteristics and ecdysteroids during the molting cycle of tiger shrimp, Penaeus monodon Fabricus. Zoological Studies 35:118-127
     
    (二)國內研討會論文National conference abstract
    Chang, CY, Kao, HW, Deng, JY, Lin, WW (2014) Functional study of autocrine motility factor receptor (amfr) in zebrafish embryonic development. 2014 Taiwan Zebrafish Symposium. National Health Research Institutes, Zhunan, Taiwan.
     
    Kao, HW, Deng, JY, Peng, YJ, Lin, WW (2011) Developmental expression of zebrafish autocrine motility factor receptor (amfr). 2011 Taiwan Zebrafish Symposium. Academia Sinica, Taipei, Taiwan.
     
    Lee, WL, Kao, HW, Lin, WW (2010) Zebrafish gpib is required for epibolic cell movement. 2010 Taiwan Zebrafish Symposium. National Health Research Institutes, Taipei, Taiwan.
     
    (三)專書 Books
    黃榮富、潘志弘、郭素芬、林文文、蔡美玲, 生物學實驗, 藝軒出版社, 2010/6/1, ISBN:978-957-616-955-7.
    Back to List
Catalogue
相關分類
瀏覽數: